Ng E K, Chung S C, Lau J T, Sung J J, Leung J W, Raimes S A, Chan A C, Li A K
Department of Surgery, Prince of Wales Hospital, Chinese University of Hong Kong.
Br J Surg. 1996 Jun;83(6):840-4. doi: 10.1002/bjs.1800830635.
To identify the risk factors for developing recurrent ulcer complications after recovery from an episode of peptic ulcer bleeding 611 patients admitted with peptic ulcer bleeding were studied. Some 557 (91 per cent) were discharged without operation. A total of 22 patients were lost to follow-up and five were excluded as maintenance H2 blockers were required. Of the remaining 530 patients at risk, 169 (32 per cent) developed another complication (166 bleeding, three perforations) over a median follow-up period of 36 months. Patients with duodenal ulcers at the time of bleeding, previous history of peptic ulcer, previous bleeding, history of dyspepsia longer than 3 months, and a short interval between previous ulcer complications and the index bleed were more likely to develop further complications. Sex, age, smoking, coexisting illness, non-steroidal anti-inflammatory drugs intake and time taken to achieve ulcer healing had no predictive value.
为了确定消化性溃疡出血发作恢复后发生复发性溃疡并发症的风险因素，我们对611例因消化性溃疡出血入院的患者进行了研究。约557例（91%）患者未经手术即出院。共有22例患者失访，5例因需要使用H2阻滞剂维持治疗而被排除。在其余530例有风险的患者中，在中位随访期36个月内，169例（32%）发生了另一种并发症（166例出血，3例穿孔）。出血时患有十二指肠溃疡、有消化性溃疡病史、既往有出血史、消化不良病史超过3个月以及既往溃疡并发症与此次出血之间间隔时间短的患者更有可能发生进一步的并发症。性别、年龄、吸烟、并存疾病、非甾体抗炎药的使用以及溃疡愈合所需时间均无预测价值。
