Conroy S E, Tucker L, Latchman D S, Isenberg D A
Bloomsbury Rheumatology Unit, Department of Medicine, University College London, U.K.
Clin Exp Rheumatol. 1996 Jan-Feb;14(1):99-104.
To determine the incidence of anti-hsp90 and 70 antibodies in children with SLE, juvenile dermatomyositis and juvenile chronic arthritis.
We utilized a previously described ELISA to detect the presence of antibodies to mammalian hsp90 and 70 in 33 children with SLE, 55 with juvenile chronic arthritis (JCA) and 11 with dermatomyositis. Sera from 19 children with non-autoimmune conditions served as controls.
Antibodies reactive with hsp90 and/or 70 were detected in 35% of the children with SLE, and the numbers of children with SLE who have raised IgG anti-hsp90 antibodies (24%) is very similar to our adult onset cases, although the prevalence of IgM antibodies is much smaller. However, serum antibodies to hsp70 were as infrequent in children with SLE or JCA as in adults with SLE or RA, although IgG antibodies to hsp70 were detected in 50% of the synovial fluid of JCA patients.
The incidence of antibodies to hsp90 in childhood-onset SLE resembles that described in adult onset disease suggesting that, despite clinical differences between the two, a subset of each may share a similar pathological mechanism of disease.
确定系统性红斑狼疮（SLE）、幼年皮肌炎和幼年慢性关节炎患儿中抗热休克蛋白90（hsp90）和70抗体的发生率。
我们采用先前描述的酶联免疫吸附测定法（ELISA），检测33例SLE患儿、55例幼年慢性关节炎（JCA）患儿和11例皮肌炎患儿体内针对哺乳动物hsp90和70的抗体。19例非自身免疫性疾病患儿的血清作为对照。
35%的SLE患儿检测到与hsp90和/或70反应的抗体，SLE患儿中IgG抗hsp90抗体升高的比例（24%）与我们的成年发病病例非常相似，尽管IgM抗体的发生率要低得多。然而，SLE或JCA患儿中抗hsp70血清抗体与SLE或类风湿关节炎（RA）成年患者一样罕见，尽管在50%的JCA患者滑液中检测到IgG抗hsp70抗体。
儿童期发病的SLE中抗hsp90抗体的发生率与成年发病疾病中所描述的相似，这表明，尽管两者在临床上存在差异，但各自的一个亚组可能具有相似的疾病病理机制。
