霍乱弧菌O1 El Tor生物型和O139菌株的定殖需要毒素协同调节菌毛，而非甘露糖敏感血凝素。
Toxin-coregulated pilus, but not mannose-sensitive hemagglutinin, is required for colonization by Vibrio cholerae O1 El Tor biotype and O139 strains.
作者信息
Thelin K H, Taylor R K
机构信息
Department of Microbiology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA.
出版信息
Infect Immun. 1996 Jul;64(7):2853-6. doi: 10.1128/iai.64.7.2853-2856.1996.
Abstract
The relative contributions of toxin-coregulated pilus (TCP) and cell-associated mannose-sensitive hemagglutinin (MSHA) to the colonization ability of Vibrio cholerae O1 El Tor biotype strains and O139 Bengal strains was determined by using isogenic parental and in-frame deletion mutant pairs in the infant mouse cholera model. Both the El Tor and O139 tcpA mutant strains showed a dramatic defect in colonization as indicated by their competitive indices, whereas deletion of mshA had a negligible effect on colonization in either background.
摘要
通过在幼鼠霍乱模型中使用同基因亲本和框内缺失突变体对，确定了毒素共调节菌毛（TCP）和细胞相关甘露糖敏感血凝素（MSHA）对霍乱弧菌O1 El Tor生物型菌株和O139孟加拉菌株定植能力的相对贡献。El Tor和O139 tcpA突变株的竞争指数表明，它们在定植方面存在显著缺陷，而在任一背景下，mshA的缺失对定植的影响都可以忽略不计。
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