Johnson J A, Salles C A, Panigrahi P, Albert M J, Wright A C, Johnson R J, Morris J G
Molecular Diagnostics Laboratory, VAMC Baltimore, MD 21201.
Infect Immun. 1994 May;62(5):2108-10. doi: 10.1128/iai.62.5.2108-2110.1994.
Although Vibrio cholerae O139 synonym Bengal strains, from the current epidemics in India and Bangladesh, are closely related to seventh-pandemic strains, as shown by multilocus enzyme electrophoresis, Bengal strains are encapsulated and portions of the O1 antigen biosynthetic complex genes found in O1 strains are altered or lacking. Encapsulated Bengal strains showed resistance to killing by normal human serum. The presence of the capsule suggests the potential for bloodstream invasion in susceptible hosts and has profound implications for vaccine development.
尽管来自印度和孟加拉国当前疫情的霍乱弧菌O139（同义词孟加拉菌株）与第七次大流行菌株密切相关，多位点酶电泳结果表明了这一点，但孟加拉菌株有荚膜，且O1菌株中发现的O1抗原生物合成复合基因部分发生了改变或缺失。有荚膜的孟加拉菌株对正常人血清杀伤具有抗性。荚膜的存在表明在易感宿主中有发生血流侵袭的可能性，并且对疫苗开发具有深远影响。
