De Koning P, Neijt J P, Jennekens F G, Gispen W H
Toxicol Appl Pharmacol. 1987 Jun 15;89(1):81-7. doi: 10.1016/0041-008x(87)90178-5.
Cisplatin neurotoxicity was studied in rats by using electrophysiological and functional tests. The drug was injected intraperitoneally two times a week (1 mg/kg) up to a cumulative dose of 19.0 mg/kg body wt. At this dose the H-reflex-related sensory nerve conduction velocity was reduced. After cessation of drug administration, the H-reflex-related sensory nerve conduction velocity slowly improved. The motor nerve conduction velocity remained unaffected throughout the intoxication period and concentric needle investigation showed no signs of denervation. In addition, the sensorimotor response to a noxious stimulus presented locally to the foot sole was not affected by the cisplatin treatment. It is concluded that measurement of H-reflex-related sensory nerve conduction velocity is a useful and accurate tool in the evaluation of cisplatin neurotoxicity in rats.
通过电生理和功能测试对大鼠顺铂神经毒性进行了研究。每周两次腹腔注射该药物（1毫克/千克），直至累积剂量达到19.0毫克/千克体重。在此剂量下，与H反射相关的感觉神经传导速度降低。停药后，与H反射相关的感觉神经传导速度缓慢改善。在整个中毒期间，运动神经传导速度未受影响，同心针检查未显示失神经支配迹象。此外，对足底局部施加的有害刺激的感觉运动反应不受顺铂治疗的影响。结论是，测量与H反射相关的感觉神经传导速度是评估大鼠顺铂神经毒性的一种有用且准确的工具。
