Jobard E, Harry P, Turcant A, Roy P M, Allain P
Laboratoire de Pharmacologie et Toxicologie, Centre Hospitalier Universitaire, Angers, France.
J Toxicol Clin Toxicol. 1996;34(4):373-7. doi: 10.3109/15563659609013806.
Two patients severely intoxicated with ethylene glycol became anuric and were treated by hemodialysis and the antidote, 4-methylpyrazole. On admission, their plasma ethylene glycol concentrations were 0.42 and 3 g/L respectively and no alcohol was detected. The elimination of 4-methylpyrazole in the dialysate represented 45% of the total body elimination. Clearances of 4-methylpyrazole by hemodialysis were 80 mL/min and 52 mL/min respectively.
In such cases, the authors propose infusion of a 4-methylpyrazole loading dose of 10-20 mg/kg before dialysis and intravenous infusion of 1-1.5 mg/kg/h during the 8-12 hours of hemodialysis to compensate the loss in dialysate.
两名严重乙二醇中毒患者出现无尿，接受了血液透析及解毒剂4-甲基吡唑治疗。入院时，他们的血浆乙二醇浓度分别为0.42 g/L和3 g/L，未检测到酒精。透析液中4-甲基吡唑的清除量占全身清除总量的45%。血液透析对4-甲基吡唑的清除率分别为80 mL/分钟和52 mL/分钟。
对于此类病例，作者建议在透析前静脉注射10 - 20 mg/kg的4-甲基吡唑负荷剂量，并在8 - 12小时的血液透析期间以1 - 1.5 mg/kg/小时的速度静脉输注，以补偿透析液中的损失。
