Harry P, Jobard E, Briand M, Caubet A, Turcant A
Centre Anti-poison, Centre Hospitalier Universitaire, Angers, France.
Pediatrics. 1998 Sep;102(3):E31. doi: 10.1542/peds.102.3.e31.
The alcohol dehydrogenase inhibitor 4-methylpyrazole (4-MP) is a new antidote of ethylene glycol (EG) intoxication. The purpose of the present case report was to demonstrate 4-MP efficiency in EG poisoning in a 4-year-old child.
4-MP Treatment was performed 7 hours after EG ingestion. Plasma EG and 4-MP concentrations were measured 2 hours after each infusion of 4-MP. Plasma 4-MP concentrations were in the range of the values reported to block EG metabolism. The efficiency of 4-MP treatment was confirmed by the rapid correction of metabolic acidosis without alkalization and by the increase in EG half-life. No adverse effect of 4-MP was observed.
This child ingested a potentially lethal dose of EG despite a high concentration of bittering agent in antifreeze. EG poisoning was treated efficiently by 4-MP without recourse to hemodialysis.
乙醇脱氢酶抑制剂4-甲基吡唑（4-MP）是乙二醇（EG）中毒的一种新型解毒剂。本病例报告的目的是证明4-MP对一名4岁儿童乙二醇中毒的疗效。
在摄入EG 7小时后进行4-MP治疗。每次输注4-MP 2小时后测定血浆EG和4-MP浓度。血浆4-MP浓度处于报告的可阻断EG代谢的值范围内。4-MP治疗的有效性通过在未进行碱化的情况下快速纠正代谢性酸中毒以及EG半衰期的延长得到证实。未观察到4-MP的不良反应。
尽管防冻剂中苦味剂浓度很高，但该儿童仍摄入了可能致命剂量的EG。4-MP有效地治疗了EG中毒，无需进行血液透析。
