Brubacher J R, Hoffman R S
New York Poison Control Center, New York 10016, USA.
J Toxicol Clin Toxicol. 1996;34(4):431-6. doi: 10.3109/15563659609013814.
Although topical salicylates are widely used, toxicity from this route is rare.
We present an unusual case of salicylism from a topical salicylate preparation in an 80-year-old woman. The patient was admitted to the dermatology service with a diagnosis of erythroderma and was treated with salicylate containing ointments. After six days of treatment the patient became confused and paranoid. A serum salicylate was 3.36 mmol/L (46 mg/dL). The patient was admitted to the intensive care unit were she was rehydrated and treated with bicarbonate and activated charcoal.
Her serum salicylate fell to 1.90 mmol/L (26 mg/dL) over a two day period and she regained a normal mental status.
尽管局部使用水杨酸盐很普遍，但通过该途径产生的毒性很罕见。
我们报告一例80岁女性因局部使用水杨酸盐制剂导致水杨酸中毒的不寻常病例。该患者因红皮病诊断入住皮肤科，接受含水杨酸盐的软膏治疗。治疗六天后，患者出现意识模糊和妄想。血清水杨酸盐水平为3.36 mmol/L（46 mg/dL）。患者被收入重症监护病房，在那里接受补液、碳酸氢盐和活性炭治疗。
两天内她的血清水杨酸盐水平降至1.90 mmol/L（26 mg/dL），精神状态恢复正常。
