Pfab R, Mückter H, Roider G, Zilker T
Walther-Straub-Institut für Pharmakologie und Toxikologie, Universität München, Germany.
J Toxicol Clin Toxicol. 1996;34(4):453-60. doi: 10.3109/15563659609013818.
A 44-year-old man ingested 83 mg/kg Thiomersal. He developed gastritis, renal tubular failure, dermatitis, gingivitis, delirium, coma, polyneuropathy and respiratory failure. Treatment was symptomatic plus gastric lavage and the oral chelating agents dimercaptopropane sulfonate and dimercaptosuccinic acid. The patient recovered completely. Maximum mercury concentrations were blood 14 mg/L, serum 1.7 mg/L, urine 10.7 mg/L, and cerebrospinal fluid 0.025 mg/L. Mercury concentration in blood declined with two velocities: first with half-time 2.2 days, then with half-time 40.5 days. The decline of mercury concentration in blood, urinary mercury excretion, and renal mercury clearance were not substantially influenced by chelation therapy.
一名44岁男性摄入了83毫克/千克的硫柳汞。他出现了胃炎、肾小管衰竭、皮炎、牙龈炎、谵妄、昏迷、多发性神经病和呼吸衰竭。治疗方法为对症治疗加洗胃，并使用口服螯合剂二巯丙磺酸钠和二巯丁二酸。患者完全康复。血液中汞的最高浓度为14毫克/升，血清中为1.7毫克/升，尿液中为10.7毫克/升，脑脊液中为0.025毫克/升。血液中汞浓度以两种速度下降：首先半衰期为2.2天，然后半衰期为40.5天。螯合疗法对血液中汞浓度的下降、尿汞排泄和肾脏汞清除率没有实质性影响。
