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法国一项涉及全科医生的下肢闭塞性动脉疾病全国性研究:阿尔泰米奥研究。

National study of obliterative arterial disease of the lower limbs involving general practitioners in France: Artemio study.

作者信息

Vray M, Chwalow J, Charansonney O, Vasmant D, Capron L, Boccalon H, Eschwege E

机构信息

INSERM U21, Villejuif, France.

出版信息

J Cardiovasc Pharmacol. 1995;25 Suppl 2:S51-7. doi: 10.1097/00005344-199500252-00011.

Abstract

A national survey was performed in France from May to June, 1993. The aim of this study was to evaluate general practitioners' attitudes and behaviors when diagnosing and managing patients with lower extremity arterial disease (LEAD). One thousand general practitioners, randomly drawn from an exhaustive list, were contacted to participate in a telephone interview concerning the last patient with intermittent claudication seen in their practice. Four hundred seventy-six general practitioners participated. Risk factors noted for these 476 patients with intermittent claudication were in agreement with the literature: 86% were men aged 64 +/- 10 years (mean +/- SD) and 14% were women aged 73 +/- 8 years. Sixty-two percent had a pain-free walking distance of between 100 and 500 meters at diagnosis. Forty-five percent were former smokers and 37% currently smoked; 55% had hypertension, 14% diabetes, and 56% disturbances of lipid metabolism. A majority of them were hypercholesterolemic. The diagnosis of the disease was based primarily on a clinical assessment, confirmed for 33% by Doppler or echo Doppler. The mean duration of diagnosis was 4.4 +/- 4.1 years. Management of the disease was mainly by prescription of vasodilators (91%), antiplatelet agents (59%), and anticoagulants (8%). Use of Doppler or echo Doppler was recommended once a year. Infection was observed in 27% of patients. Thirty-eight percent had had a cardiac incident (angina pectoris or myocardial infarction) and 10% a cerebrovascular accident. They differed significantly from those with LEAD alone for the following parameters: age (68.5 +/- 9.2 vs. 63.2 +/- 10.3 years; p < 0.001); duration of LEAD (5.6 +/- 4.6 vs. 3.6 +/- 3.5 years; p < 0.001); hypertension (65% vs. 50%; p < 0.01); and current smoking (29% vs. 43%; p < 0.01). This survey confirmed the feasibility of telephone interviewing, on a large sample of general practitioners in France. The high level of association with other cardiac incidents was, for these patients, a much higher risk of mortality and morbidity than LEAD alone. It would be interesting to validate the associations observed with a prospective study of comorbidity.

摘要

1993年5月至6月在法国进行了一项全国性调查。本研究的目的是评估全科医生在诊断和管理下肢动脉疾病(LEAD)患者时的态度和行为。从一份详尽的名单中随机抽取了1000名全科医生,联系他们就其诊所中最近诊治的一名间歇性跛行患者进行电话访谈。476名全科医生参与了调查。这476名间歇性跛行患者的危险因素与文献一致:86%为64±10岁(均值±标准差)的男性,14%为73±8岁的女性。62%的患者在诊断时无痛行走距离为100至500米。45%为既往吸烟者,37%为当前吸烟者;55%患有高血压,14%患有糖尿病,56%存在脂质代谢紊乱。他们中的大多数人患有高胆固醇血症。该疾病的诊断主要基于临床评估,33%通过多普勒或超声多普勒得到证实。诊断的平均时长为4.4±4.1年。该疾病的管理主要通过开具血管扩张剂(91%)、抗血小板药物(59%)和抗凝剂(8%)。建议每年进行一次多普勒或超声多普勒检查。27%的患者出现感染。38%的患者发生过心脏事件(心绞痛或心肌梗死),10%的患者发生过脑血管意外。他们在以下参数方面与单纯患有LEAD的患者有显著差异:年龄(68.5±9.2岁对63.2±10.3岁;p<0.001);LEAD病程(5.6±4.6年对3.6±3.5年;p<0.001);高血压(65%对50%;p<0.01);以及当前吸烟情况(29%对43%;p<0.01)。这项调查证实了在法国对大量全科医生进行电话访谈的可行性。对于这些患者而言,与其他心脏事件的高度关联意味着其死亡和发病风险比单纯的LEAD要高得多。通过对合并症的前瞻性研究来验证所观察到的关联将会很有意思。

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