Fiessinger J N
Service de Médecine Vasculaire, Hôpital Broussais, Paris, France.
Drugs. 1998;56 Suppl 3:11-6. doi: 10.2165/00003495-199856003-00002.
The therapeutic management of patients with peripheral arterial disease relies initially on the assessment of the severity of arterial insufficiency. At this stage, measurement of ankle systolic pressure plays a particularly important role, and is an essential part of the clinical examination. When the severity of ischaemia jeopardises the survival of a limb, the limitations associated with medical treatment clearly justify all steps being taken to enable the patient to benefit from revascularisation. In this often fragile host environment, endovascular techniques play an important part. As first-line procedures, they have a place within a multidisciplinary management approach, particularly since further surgical procedures, such as distal bypass, often prove necessary. For patients at the intermittent claudication stage, treatment indications become more complex. They include the functional repercussions of peripheral arterial occlusive disease and the cardiovascular prognosis for the patient, which is determined by assessing the extent of the arterial disease. Ultrasonography provides a topographical evaluation of the lesions and their haemodynamic repercussions. This investigation is crucial for screening patients who present with a lesion that may be appropriate for endovascular surgery. Ultrasonography is often programmed at the same time as arteriography. For patients with intermittent claudication, surgical revascularisation is considered only after a minimum 3-month period of medical treatment, for those who have significant functional impairment. In some instances, ultrasonographic evaluation, or even arteriography, may reveal lesions associated with a real risk of deterioration, such as arterial or popliteal aneurysm, and this constitutes the basis of the indication. The development of endovascular techniques has broadened the indications for surgical revascularisation to include patients with intermittent claudication. As a result, there has been a radical change with regard to the management of these patients, limiting the number for whom medical treatment is the only feasible solution.
外周动脉疾病患者的治疗管理最初依赖于对动脉供血不足严重程度的评估。在这个阶段,测量踝部收缩压起着特别重要的作用,并且是临床检查的重要组成部分。当缺血的严重程度危及肢体存活时,与药物治疗相关的局限性显然证明应采取一切措施使患者能够从血运重建中获益。在这种通常较为脆弱的机体环境中,血管内技术发挥着重要作用。作为一线治疗手段,它们在多学科管理方法中占有一席之地,特别是因为往往有必要进行进一步的外科手术,如远端旁路手术。对于处于间歇性跛行阶段的患者,治疗指征变得更加复杂。这些指征包括外周动脉闭塞性疾病的功能影响以及患者的心血管预后,而心血管预后是通过评估动脉疾病的范围来确定的。超声检查可对病变及其血流动力学影响进行局部评估。这项检查对于筛查可能适合血管内手术的病变患者至关重要。超声检查通常与动脉造影同时安排。对于间歇性跛行患者,只有在经过至少3个月的药物治疗后,对于那些有明显功能障碍的患者才考虑进行外科血运重建。在某些情况下,超声评估甚至动脉造影可能会发现与真正恶化风险相关的病变,如动脉瘤或腘动脉瘤,这构成了治疗指征的依据。血管内技术的发展拓宽了外科血运重建的指征,将间歇性跛行患者也包括在内。结果,这些患者的治疗管理发生了根本性变化,减少了仅以药物治疗作为唯一可行解决方案的患者数量。