The effect of intracutaneous injections of micronized crystalline suspensions of nandrolone phenyl-propionate in the skin of female hairless hamsters.

Single intracutaneous injections of micronized crystalline suspensions of nandrolone phenylpro-pionate have been shown to induce local thickening of the epidermis of female hairless hamsters, accompanied by a marked increase in sebaceous gland volume over a period of 7 days. It is known that certain materials, when injected intracutaneously, may produce a diffuse inflammatory response in the dermis which in turn causes hyperplasia in the adjacent epidermis. The response observed in the present case, however, is clearly specific to nandrolone phenylpropionate, and cannot be attributed to an inflammatory response of the dermis to intracutaneously injected crystalline material.