Lanska M J, Lanska D J
Lexington-Fayette County Health Department, KY 40508, USA.
Neuroepidemiology. 1996;15(3):117-25. doi: 10.1159/000109898.
We present nationally representative estimates of neonatal seizure risk by gender, race and geographic region of the United States. National Hospital Discharge Survey data were analyzed for the period 1980-1991. Birth-weight-adjusted risks of neonatal seizures were calculated by the direct method for each gender or race group and for each census region by 4-year intervals. The overall risk of neonatal seizures was 2.84 per 1,000 live births. Risk estimates were consistently higher in low-birth-weight infants (relative risk 3.9). Unadjusted risks were similar across race and gender groups; birth weight adjustment had very little effect. No clear temporal trend was apparent over the 12-year study period. National Hospital Discharge Survey data provide reasonable, although conservative, estimates of neonatal seizure risks nationwide. Underascertainment of neonatal seizures, particularly among sick low-birth-weight infants, is likely due to data collection limitations of the National Hospital Discharge Survey.
我们提供了按美国性别、种族和地理区域划分的新生儿癫痫发作风险的全国代表性估计值。对1980 - 1991年期间的国家医院出院调查数据进行了分析。通过直接法计算了每个性别或种族组以及每个普查区域每4年间隔的出生体重调整后的新生儿癫痫发作风险。新生儿癫痫发作的总体风险为每1000例活产中有2.84例。低出生体重婴儿的风险估计始终较高（相对风险为3.9）。种族和性别组之间未经调整的风险相似；出生体重调整的影响很小。在12年的研究期间没有明显的时间趋势。国家医院出院调查数据提供了全国范围内新生儿癫痫发作风险的合理估计，尽管较为保守。新生儿癫痫发作的漏报，尤其是在患病的低出生体重婴儿中，可能是由于国家医院出院调查的数据收集限制所致。
