Sheid B, Lu T, Pedrinan L, Nelson J H
Cancer. 1977 May;39(5):2204-8. doi: 10.1002/1097-0142(197705)39:5<2204::aid-cncr2820390539>3.0.co;2-y.
There were no significant differences between the mean blood plasma (leukocyte-free) RNAase activity among 128 healthy women volunteers age 13-70 and 49 women with benign gynecological tumors. Exceptions to this finding were three apparently healthy women volunteers who had plasma enzyme activity which was higher than two standard deviations from the mean of the control subjects. Increased plasma RNAase activity was also demonstrated for 21 of 22 patients with ovarian carcinomas of differential histological types. This group included two patients with Stage IA, two patients with Stage IC ovarian carcinoma, and 17 patients with advanced ovarian carcinoma. The one exception was a patient with a well encapsulated, mucinous cystadenocarcinoma, Stage IA. The plasma RNAase activity returned to normal values in all of the cancer patients who had no clinical evidence of residual malignant tissue after surgical treatment. However, the enzyme activity also returned to a normal value in one of the 17 women in whom all of the malignant tissue was not removed. These data indicate that plasma RNAase activity can be utilized as a tumor marker for the presence of ovarian malignancies of various histological types, and to differentiate between malignant and benign neoplasms.
128名年龄在13至70岁的健康女性志愿者与49名患有良性妇科肿瘤的女性的平均血浆（无白细胞）RNA酶活性之间没有显著差异。这一发现的例外情况是三名明显健康的女性志愿者，她们的血浆酶活性高于对照组平均值两个标准差。在22例不同组织学类型的卵巢癌患者中，有21例也表现出血浆RNA酶活性增加。该组包括两名IA期患者、两名IC期卵巢癌患者和17例晚期卵巢癌患者。唯一的例外是一名IA期、包膜完整的黏液性囊腺癌患者。在所有接受手术治疗后无残留恶性组织临床证据的癌症患者中，血浆RNA酶活性恢复到正常值。然而，在17名未完全切除所有恶性组织的女性中，有一名女性的酶活性也恢复到了正常值。这些数据表明，血浆RNA酶活性可作为各种组织学类型卵巢恶性肿瘤存在的肿瘤标志物，并用于区分恶性和良性肿瘤。
