N 末端和 C 末端心房利钠肽血浆浓度在室温下的稳定性。
Stability of plasma concentrations of N and C terminal atrial natriuretic peptides at room temperature.
作者信息
Cleland J G, Ward S, Dutka D, Habib F, Impallomeni M, Morton I J
机构信息
MRC Clinical Research Initiative in Heart Failure, University of Glasgow.
出版信息
Heart. 1996 Apr;75(4):410-3. doi: 10.1136/hrt.75.4.410.
BACKGROUND
Plasma concentrations of atrial natriuretic peptide (ANP) are increased in patients with ventricular dysfunction and could have a diagnostic role in heart failure. ANP may be unstable after collection, however, limiting any practical diagnostic role.
METHODS
Blood samples were obtained from 18 patients with various conditions. Aliquots were either processed optimally or kept as blood or plasma at room temperature for 6-72 h before processing.
RESULTS
Concentrations of C-terminal ANP were lower in specimens kept as blood for 24 and 72 h (mean difference from control -43% and -76%, respectively, (P < 0.001) but N-terminal ANP (extracted) seemed to be stable under all conditions studied (-2% at 24 h and -7% at 72 h, not significant).
CONCLUSIONS
N-terminal ANP (extracted) is stable and potentially has a role in the diagnosis of heart failure in routine clinical practice.
背景
心室功能不全患者的血浆心钠素（ANP）浓度升高，其可能在心力衰竭诊断中发挥作用。然而，采集后ANP可能不稳定，限制了其实际诊断作用。
方法
从18例患有各种病症的患者中采集血样。将等分试样进行最佳处理，或在处理前于室温下作为血液或血浆保存6 - 72小时。
结果
保存为血液24小时和72小时的标本中，C端ANP浓度较低（与对照组的平均差异分别为-43%和-76%，P < 0.001），但N端ANP（提取的）在所有研究条件下似乎都稳定（24小时时为-2%，72小时时为-7%，无显著差异）。
结论
N端ANP（提取的）稳定，在常规临床实践中可能对心力衰竭的诊断有作用。
Zotero 插件