Wilson M, Burns T, Pratten J
Department of Microbiology, Eastman Dental Institute of Oral Health Care Sciences, University of London, UK.
J Antimicrob Chemother. 1996 Feb;37(2):377-81. doi: 10.1093/jac/37.2.377.
The aim of this study was to determine whether Streptococcus sanguis, when in a biofilm, could be killed using a light-activated antimicrobial agent. Biofilms were grown on hydroxyapatite, irradiated with up to 12.2 J of light from a gallium aluminium arsenide laser in the presence of aluminium disulphonated phthalocyanine (AlPcS2) and survivors enumerated. No significant decrease in the viable count was found when either the AlPcS2 or the laser light was used alone. There was a light dose related decrease in the viable counts of irradiated AlPcS2-treated biofilms. No viable streptococci were detectable following irradiation with 12.2 J of laser light.
本研究的目的是确定血链球菌在生物膜状态下能否被光激活抗菌剂杀灭。生物膜在羟基磷灰石上生长，在二磺酸铝酞菁（AlPcS2）存在的情况下，用砷化镓铝激光照射高达12.2焦耳的光，并对存活菌进行计数。单独使用AlPcS2或激光时，活菌数均未发现显著下降。经AlPcS2处理的生物膜在照射后活菌数出现与光剂量相关的下降。用12.2焦耳激光照射后未检测到存活的链球菌。
