Kim T H, Cho Y H, Park H B
Department of Dermatology, Gyeongsang National University Hospital, South Korea.
J Dermatol. 1996 Jun;23(6):419-24. doi: 10.1111/j.1346-8138.1996.tb04045.x.
We report two cases of pachydermodactyly. Case 1 was a 16-year-old girl who complained of asymptomatic, bulbous, firm swellings which developed insidiously on both sides of the proximal interphalangeal (PIP) joint of her right middle finger. Case 2 was a 14-year-old boy with similar lesions on the sides of the PIP joints of the index and middle fingers of both hands. They both had histories of mild, repetitive mechanical trauma of the fingers. Radiologic findings showed soft tissue swellings without any bony or articular abnormalities. Histopathologic findings from the bulbous swellings revealed marked hyperkeratosis, slight epidermal hyperplasia, and a markedly thickened dermis with a deposition of mucinous material among the collagen fibers. Ultrastructural examinations of both cases showed decreased diameters of collagen fibrils. The lesions temporarily improved with intralesional injection of triamcinolone acetonide. Pachydermodactyly is more commonly found in boys and the affected fingers are more numerous in boys. Both of the present cases had the habit of rubbing and gripping their fingers unconsciously. Mechanical trauma of the fingers around puberty may play an important role in pachydermodactyly.
我们报告两例厚皮性指端皮炎。病例1是一名16岁女孩,她主诉右手中指近端指间关节(PIP)两侧隐匿出现无症状的球根状、坚实肿胀。病例2是一名14岁男孩,双手示指和中指的PIP关节两侧有类似病变。他们都有手指轻度、重复性机械性创伤史。影像学检查结果显示软组织肿胀,无任何骨质或关节异常。球根状肿胀的组织病理学检查结果显示明显的角化过度、轻度表皮增生,以及真皮明显增厚,胶原纤维间有黏液样物质沉积。两例的超微结构检查均显示胶原原纤维直径减小。病变经曲安奈德皮损内注射后暂时改善。厚皮性指端皮炎在男孩中更常见,且男孩受影响的手指更多。本两例患者均有不自觉摩擦和紧握手指的习惯。青春期前后手指的机械性创伤可能在厚皮性指端皮炎中起重要作用。