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地西泮对猪因消退而被抑制行为的影响。

Effects of diazepam on behaviour suppressed by extinction in pigs.

作者信息

Dantzer R

出版信息

Pharmacol Biochem Behav. 1977 Feb;6(2):157-61. doi: 10.1016/0091-3057(77)90066-1.

DOI:10.1016/0091-3057(77)90066-1
PMID:870903
Abstract

Diazepam injected to pigs previously trained to perform an operant response for food according to a continuous reinforcement schedule significantly increased resistance to extinction compared to control pigs. In pigs submitted to a time-out procedure diazepam increased the number of nonreinforced responses at the beginning of the acquisition but was unable to disinhibit suppressed behaviour in the later stages of acquisition when the extinguished behaviour was well acquired. The results are discussed with respect to antiaversive or disinhibitory effects of benzodiazepines and an alternative interpretation, the strengthening of the prevailing behavioural tendency in the animal's repertoire at the time of test, is put forward.

摘要

给先前按照连续强化程序训练为获取食物而做出操作性反应的猪注射地西泮,与对照猪相比,其对消退的抵抗力显著增强。在接受暂停程序的猪中,地西泮在习得开始时增加了无强化反应的次数,但在习得后期,当消退行为已充分习得时,它无法解除被抑制的行为。结合苯二氮䓬类药物的抗厌恶或解除抑制作用对结果进行了讨论,并提出了另一种解释,即在测试时强化动物行为库中占主导地位的行为倾向。

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引用本文的文献

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Reduced behavioral variability in extinction: effects of chronic treatment with the benzodiazepine, diazepam or with ethanol.消退过程中行为变异性降低:苯二氮䓬类药物地西泮或乙醇长期治疗的影响
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Behavioral analysis of diazepam-induced memory deficits: evidence for sedation-like effects.
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[Effects of diazepam on exploratory behavior of pigs (author's transl)].
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