Los F J, Noomen P, Vermeij-Keers C, Gaillard J L, Brandenburg H, Jahoda M G, Luider T M
Department of Clinical Genetics, University Hospital Dijkzigt, Erasmus University Rotterdam, The Netherlands.
Prenat Diagn. 1996 Mar;16(3):193-8. doi: 10.1002/(SICI)1097-0223(199603)16:3<193::AID-PD827>3.0.CO;2-R.
Experimental materno-embryonic transfusions with serum that is immunologically active against blood group antigens cause congenital malformations in the rat embryo. In view of the possible increased incidence of vascular disruptive syndromes after chorionic villus sampling (CVS), we investigated the occurrence of materno-fetal transfusions (MFTs) in this procedure. In 18 pregnant women experiencing two needle introductions at CVS, we looked immunohistochemically at the presence of haemoglobin A1-containing maternal erythrocytes in the fetal circulation of the separately collected first and second chorionic villus samples. In 4 of 18 patients (22 per cent), a significant increase of maternal cells was observed in the second sample compared with the first sample, indicating the occurrence of MFT by CVS. On the rare occasion of maternal immunization against fetal antigens, a CVS-associated MFT might provoke immunological damage to the fetus.
用对血型抗原有免疫活性的血清进行实验性母胎输血会导致大鼠胚胎出现先天性畸形。鉴于绒毛取样（CVS）后血管破坏综合征的发病率可能增加，我们研究了该操作中母胎输血（MFT）的发生情况。在18名接受两次CVS进针的孕妇中，我们通过免疫组织化学方法检测了分别采集的第一份和第二份绒毛样本的胎儿循环中含血红蛋白A1的母体红细胞的存在情况。在18名患者中有4名（22%），与第一份样本相比，第二份样本中母体细胞显著增加，表明CVS发生了MFT。在罕见的母体针对胎儿抗原免疫的情况下，与CVS相关的MFT可能会对胎儿造成免疫损伤。
