Bruce R A, DeRouen T, Peterson D R, Irving J B, Chinn N, Blake B, Hofer V
Am J Cardiol. 1977 May 26;39(6):833-40. doi: 10.1016/s0002-9149(77)80036-2.
In a follow-up study of 1,852 men with coronary heart disease, 195 deaths occurred within the first 3 years (33 +/- 13 months [mean +/- standard deviation]). Analysis of these cases indicated that the risk of sudden cardiac death in ambulatory men with clinical manifestations of coronary heart disease may be readily estimated from noninvasive clinical and exercise criteria. The important predictors are indexes of the severity of coronary heart disease and impairment of peak left ventricular function demonstrated with symptom-limited maximal exercise. The advantages of these predictors are that they may be elicited on the initial study as well as on follow-up noninvasive examinations of ambulatory patients. The appearance of nonelectrocardiographic predictors in serial examinations may provide an indication for invasive studies and be a more important finding than the ischemic S-T reponse to exertion.
在一项对1852名冠心病男性患者的随访研究中，195例死亡发生在最初3年内（33±13个月[均值±标准差]）。对这些病例的分析表明，有冠心病临床表现的非卧床男性心脏性猝死风险可通过无创临床和运动标准轻易估算。重要的预测因素是冠心病严重程度指标以及症状限制最大运动时所显示的左心室功能峰值受损情况。这些预测因素的优势在于，它们可在初始研究以及对非卧床患者的随访无创检查中得出。连续检查中出现的非心电图预测因素可能为侵入性研究提供指征，并且比运动时缺血性S-T反应是更重要的发现。
