Ji Y, Tao L, Xu H L, Rao M R
Department of Cardiovascular Pharmacology, Nanjing Medical University.
Yao Xue Xue Bao. 1995 Dec;30(12):886-90.
In two-kidney-one-clip (2k-1c) renovascular hypertensive rats, the blood pressure, left ventricular weight/body weight (LVW/BW) ratio and blood platelet aggregation were increased significantly. Enalapril (Ena) 6 mg . kg-1 . d-1 ig 9 wk and Taurine 30 mg . kg-1 . d-1 ig 9 wk can not only decrease the high blood pressure, LVW/BW ratio, but also the blood platelet aggregation induced by ADP or thrombin, though still different from that of the normal group. When the 2k-1c renovascular hypertensive rats were treated with both Ena and Tau, the blood pressure and blood platelet aggregation were decreased to the same as that of the normal group, and the LVW/BW ratio was also lowered markedly, though still higher than that of the normal group. These results show that both Ena and Tau can reverse the left ventricular hypertrophy, decrease the blood pressure and suppress the blood platelet aggregation in 2k-1c renovascular hypertensive rats. When treated with both drugs, the effects can be improved. It suggests that the two drugs can enhance the effects when used together, and that they may be two good agents for treatment of hypertension.
在两肾一夹（2k-1c）肾血管性高血压大鼠中，血压、左心室重量/体重（LVW/BW）比值和血小板聚集显著增加。依那普利（Ena）6毫克·千克⁻¹·天⁻¹灌胃9周和牛磺酸30毫克·千克⁻¹·天⁻¹灌胃9周不仅能降低高血压、LVW/BW比值，还能降低由ADP或凝血酶诱导的血小板聚集，尽管仍与正常组不同。当用Ena和牛磺酸同时治疗2k-1c肾血管性高血压大鼠时，血压和血小板聚集降低至与正常组相同，LVW/BW比值也明显降低，尽管仍高于正常组。这些结果表明，Ena和牛磺酸均可逆转2k-1c肾血管性高血压大鼠的左心室肥厚，降低血压并抑制血小板聚集。当两种药物同时使用时，效果可以改善。这表明两种药物联合使用时可增强疗效，且它们可能是治疗高血压的两种良好药物。
