Maiello A, Ossola O, Guidetti A, Zotti C, Moiraghi Ruggenini A
Laboratorio di Sanità Pubblica, USSL 51, Novara.
Ann Ist Super Sanita. 1995;31(3):317-22.
In order to assess the immunity/receptivity towards the three poliovirus strains, a sample representative of the sex and age composition of the resident population in Piedmont at census 1981, was examined. For each subject data were collected in order to identify the population from social-ambient point of view. For the evaluation of antibodie's title to poliovirus 1, 2, 3, the serums were analyzed with the neutralization method using the microtitolation plates and epithelial larynx cancer cells (HEp-2), like revealing system. The samples with > or = 2 title were considered positives for specific antibodies. To determine the relation between presence/absence of specific poliovirus antibodies and the other variables, a multiple logistic regression was fitted and the odds ratio was calculated. The results of our study show an immunity in all age groups, underlying a herd immunity condition. Furthermore the incomplete antibodies response to the three poliovirus strains seems to be influenced by age only.
为了评估对三种脊髓灰质炎病毒株的免疫/易感性，我们对1981年人口普查时皮埃蒙特常住人口的性别和年龄构成具有代表性的样本进行了检测。为每位受试者收集数据，以便从社会环境角度识别该人群。为了评估针对脊髓灰质炎病毒1型、2型、3型的抗体滴度，使用微量滴定板和喉癌细胞（HEp-2）作为检测系统，采用中和法对血清进行分析。抗体滴度≥2的样本被视为特异性抗体阳性。为了确定特异性脊髓灰质炎病毒抗体的存在与否与其他变量之间的关系，我们进行了多元逻辑回归分析并计算了优势比。我们的研究结果显示所有年龄组均存在免疫力，这表明存在群体免疫状况。此外，对三种脊髓灰质炎病毒株的不完全抗体反应似乎仅受年龄影响。
