Dabbert C B, Lochmiller R L, Morton R J, Powell K C
Department of Zoology, Oklahoma State University, Stillwater 74078, USA.
Avian Dis. 1996 Jan-Mar;40(1):99-102.
A pathogenic challenge model causing approximately 50% mortality was developed in adult Northern bobwhite (Colinus virginianus) using Avichol, a live vaccine containing the Clemson University (CU) strain of Pasteurella multocida Type 3. A dose of 2300 or 3000 colony-forming units (CFU) of Avichol injected intramuscularly resulted in 30 to 75% mortality, whereas a dose of 230 CFU or less resulted in no mortality, and 58,720 CFU or more resulted in death in all birds challenged. Primary and secondary vaccination of Northern bobwhite with a formalinized anaculture of Avichol -derived P. multocida resulted in protection against challenge in three separate experiments. Dexamethasone treatment of birds during vaccination resulted in decreased protection against challenge exposure.
利用一种名为Avichol的含有克莱姆森大学（CU）3型多杀性巴氏杆菌菌株的活疫苗，在成年北部 bobwhite（Colinus virginianus）中建立了一种导致约50%死亡率的致病挑战模型。肌肉注射2300或3000个菌落形成单位（CFU）的Avichol导致30%至75%的死亡率，而230 CFU或更低的剂量则不会导致死亡，58720 CFU或更高的剂量会导致所有受挑战鸟类死亡。在三个独立实验中，用甲醛灭活的源自Avichol的多杀性巴氏杆菌培养物对北部bobwhite进行初次和二次疫苗接种，可提供针对挑战的保护。在疫苗接种期间用 dexamethasone 治疗鸟类会导致针对挑战暴露的保护作用降低。
