Sengupta M, Sengupta O
Department of Pharmaceutical Technology, Jadavpur University, Calcutta.
Indian J Biochem Biophys. 1995 Oct;32(5):302-7.
Goat blood, when incubated for different periods with diloxanide furoate, metronidazole and emetine hydrochloride, underwent changes in fatty acid constituents and their peroxidation products measured as malonaldehyde. These findings, together with the changes noted in the drug-lipid partition coefficient, are discussed in an attempt to correlate the lipid constitution and biological activity of the drugs.
将山羊血分别与二氯尼特糠酸酯、甲硝唑和盐酸依米丁孵育不同时间后，其脂肪酸成分及其以丙二醛衡量的过氧化产物发生了变化。结合药物 - 脂质分配系数的变化对这些发现进行了讨论，以试图关联药物的脂质组成与生物活性。
