Mathers W D, Lane J A, Zimmerman M B
Ophthalmology Department, University of Iowa, Iowa City, USA.
Cornea. 1996 May;15(3):229-34. doi: 10.1097/00003226-199605000-00001.
We examined a group of normal subjects to evaluate the tear film function by measuring reflex tear capacity using the Schirmer test without anesthetic, steady state tear flow using fluorophotometry, meibomian gland function based on gland drop-out, expressible lipid volume and viscosity, tear loss from evaporation, and tear osmolarity. We found the average tear flow to be 0.19 +/- 0.19 microliters/min, lower than previously measured. The average tear volume was also correspondingly less, 2.74 +/- 2.0 microliters. We found there was a decline associated with advancing age for all parameters except the decay constant and lipid volume. The highest correlations with aging were tear volume (-0.64), Schirmer test (-0.63), and tear osmolarity (0.59). Our results indicate that there is a decline in tear film function throughout life and that tear flow is considerably less than previously estimated.
我们检查了一组正常受试者，通过使用无麻醉的Schirmer试验测量反射性泪液分泌能力、使用荧光光度法测量稳态泪液流量、基于睑板腺缺失情况评估睑板腺功能、测量可表达脂质体积和粘度、测量泪液蒸发损失以及测量泪液渗透压，来评估泪膜功能。我们发现平均泪液流量为0.19±0.19微升/分钟，低于先前测量值。平均泪液体积也相应较少，为2.74±2.0微升。我们发现，除了衰减常数和脂质体积外，所有参数都随年龄增长而下降。与衰老相关性最高的是泪液体积（-0.64）、Schirmer试验（-0.63）和泪液渗透压（0.59）。我们的结果表明，泪膜功能在一生中都会下降，并且泪液流量远低于先前估计值。
