月经周期中血清和胆汁脂质浓度的波动。
Fluctuations of serum and bile lipid concentrations during the menstrual cycle.
作者信息
Low-Beer T S, Wicks A C, Heaton K W, Durrington P, Yeates J
出版信息
Br Med J. 1977 Jun 18;1(6076):1568-70. doi: 10.1136/bmj.1.6076.1568.
Abstract
We measured fasting serum and bile lipid concentrations at three intervals during the normal menstrual cycles of 11 healthy women not taking oral contraceptives. In nine of them cholesterol saturation of bile, and therefore presumably the risk of developing gall stones, was higher nine days after midcycle than at the end of menstruation. This change in bile cholesterol saturation was preceded by a significant fall in serum lipid concentrations: during the nine days after mid-cycle serum triglyceride and cholesterol concentrations fell in nine and eight of the 11 women respectively. Changes in the composition of serum and biliary lipids during the menstrual cycle are presumably due to a direct effect of sex hormones on the liver.
摘要
我们在11名未服用口服避孕药的健康女性的正常月经周期中的三个时间点测量了空腹血清和胆汁脂质浓度。其中9名女性在月经周期中期过后九天时胆汁中的胆固醇饱和度较高，因此推测其患胆结石的风险也较高，而在月经结束时胆固醇饱和度较低。胆汁胆固醇饱和度的这种变化之前血清脂质浓度有显著下降：在月经周期中期过后的九天里，11名女性中有9名的血清甘油三酯浓度下降，8名的血清胆固醇浓度下降。月经周期中血清和胆汁脂质成分的变化大概是由于性激素对肝脏的直接作用。
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