Taguchi N, Ishikawa T, Sato J, Nishino T
Department of Anesthesiology, School of Medicine, Chiba University, Japan.
J Pain Symptom Manage. 1996 Jul;12(1):11-7. doi: 10.1016/0885-3924(96)00043-7.
Treatment of dyspnea in patients with advanced cancer is an important issue. The purpose of the present study was to assess the effect of induced-metabolic alkalosis produced by administration of sodium bicarbonate on dyspneic sensation. In seven healthy subjects, dyspnea was induced by having them breathe with a flow-resistive load (24 cm H2O/L/sec) for 6 min before and after administration of sodium bicarbonate (0.5 mmol/kg, per os+2 mmol/kg, IV). The intensity of dyspnea was rated using a visual analogue scale (VAS). The VAS scores and minute ventilation during loaded breathing after administration of sodium bicarbonate were significantly lower than those before administration of sodium bicarbonate. These results indicate that induced metabolic alkalosis may alleviate the intensity of dyspneic sensation by a reduction in ventilatory drive.
晚期癌症患者呼吸困难的治疗是一个重要问题。本研究的目的是评估给予碳酸氢钠所产生的诱导代谢性碱中毒对呼吸困难感觉的影响。在7名健康受试者中，在给予碳酸氢钠（0.5 mmol/kg，口服 + 2 mmol/kg，静脉注射）之前和之后，让他们使用流量阻力负荷（24 cm H₂O/L/秒）呼吸6分钟来诱发呼吸困难。使用视觉模拟量表（VAS）对呼吸困难的强度进行评分。给予碳酸氢钠后负荷呼吸期间的VAS评分和分钟通气量显著低于给予碳酸氢钠之前。这些结果表明，诱导代谢性碱中毒可能通过降低通气驱动来减轻呼吸困难感觉的强度。
