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血管加压素和催产素受体特异性激动剂及拮抗剂的设计、合成与一些用途。

Design, synthesis and some uses of receptor-specific agonists and antagonists of vasopressin and oxytocin.

作者信息

Manning M, Sawyer W H

机构信息

Department of Biochemistry and Molecular Biology, Medical College of Ohio, Toledo 43699-0008.

出版信息

J Recept Res. 1993;13(1-4):195-214. doi: 10.3109/10799899309073655.

DOI:10.3109/10799899309073655
PMID:8383753
Abstract

Selective agonists and antagonists are powerful tools for studies on AVP and OT receptors and on the physiological and pathophysiological roles of AVP and OT. Here we show how some of these peptides and their radiolabelled derivatives were designed. We also present examples of the currently available cyclic and linear OT and AVP agonists and antagonists from our laboratories.

摘要

选择性激动剂和拮抗剂是研究抗利尿激素（AVP）和催产素（OT）受体以及AVP和OT的生理和病理生理作用的有力工具。在此，我们展示了其中一些肽及其放射性标记衍生物是如何设计的。我们还列举了来自我们实验室的目前可用的环状和线性OT及AVP激动剂和拮抗剂的实例。

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