The effects of an inhibitor of aromatization (1,4,6-androstatriene-3,17-dione) and an anti-estrogen (Cl-628) on in vivo formed testosterone metabolites recovered from neonatal rat brain tissues and purified cell nuclei. Implications for sexual differentiation of the rat brain.

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作者信息

Lieberburg I, Wallach G, McEwen B S

出版信息

Brain Res. 1977 Jun 3;128(1):176-81. doi: 10.1016/0006-8993(77)90247-5.

DOI:10.1016/0006-8993(77)90247-5

PMID:871906

Abstract

摘要

相似文献

The effects of an inhibitor of aromatization (1,4,6-androstatriene-3,17-dione) and an anti-estrogen (Cl-628) on in vivo formed testosterone metabolites recovered from neonatal rat brain tissues and purified cell nuclei. Implications for sexual differentiation of the rat brain.

Brain Res. 1977 Jun 3;128(1):176-81. doi: 10.1016/0006-8993(77)90247-5.

Aromatization: important for sexual differentiation of the neonatal rat brain.芳香化作用：对新生大鼠大脑的性别分化至关重要。

Horm Behav. 1977 Dec;9(3):249-63. doi: 10.1016/0018-506x(77)90060-5.

Effect of an inhibitor of aromatization, 1,4,6 androstatriene-3,17-dione (ATD) on LH release and steroid binding in hypothalamus of adult female rats.芳香化酶抑制剂1,4,6-雄甾三烯-3,17-二酮（ATD）对成年雌性大鼠下丘脑促黄体生成素释放及类固醇结合的影响。

Exp Brain Res. 1986;64(3):407-10. doi: 10.1007/BF00340477.

Attenuating the defeminization of the neonatal rat brain: mechanisms of action of cyproterone acetate, 1,4,6-androstatriene-3,17,-dione and a synthetic progestin, R5020.减轻新生大鼠脑的去雌性化：醋酸环丙孕酮、1,4,6-雄甾三烯-3,17-二酮及合成孕激素R5020的作用机制

Horm Behav. 1979 Dec;13(3):269-81. doi: 10.1016/0018-506x(79)90044-8.

Antiestrogens: effects of tamoxifen, nafoxidine, and CI-628 on sexual behavior, cytoplasmic receptors, and nuclear binding of estrogen.抗雌激素：他莫昔芬、萘福昔定和CI-628对性行为、细胞质受体及雌激素核结合的影响

Horm Behav. 1979 Oct;13(2):97-112. doi: 10.1016/0018-506x(79)90050-3.

Sex differences in progesterone receptor expression: a potential mechanism for estradiol-mediated sexual differentiation.孕酮受体表达中的性别差异：雌二醇介导的性别分化的潜在机制。

Endocrinology. 2002 Oct;143(10):3727-39. doi: 10.1210/en.2002-211438.

Relationships between the effects of the anti-estrogen, CI-628, on sexual behavior, uterine growth, and cell nuclear estrogen retention after estradiol-17beta-benzoate administration in the ovariectomized rat.抗雌激素CI-628对去卵巢大鼠注射17β-雌二醇苯甲酸酯后的性行为、子宫生长及细胞核雌激素潴留的影响之间的关系。

Brain Res. 1977 Sep 9;133(1):119-38. doi: 10.1016/0006-8993(77)90053-1.

The capacity of the antiestrogen CI-628 to activate the estrogen receptor in vitro.抗雌激素CI-628在体外激活雌激素受体的能力。

Endocrinology. 1981 Jan;108(1):206-12. doi: 10.1210/endo-108-1-206.

Free estradiol in serum and brain uptake of estradiol during fetal and neonatal sexual differentiation in female rats.雌性大鼠胎儿期和新生儿期性别分化过程中血清中的游离雌二醇及雌二醇的脑摄取情况。

Biol Reprod. 1995 Nov;53(5):1198-207. doi: 10.1095/biolreprod53.5.1198.

Behavioral action of estrogen in male hamsters: effect of the aromatase inhibitor, 1,4,6-androstatriene-3,17-dione (ATD).雌激素对雄性仓鼠的行为作用：芳香化酶抑制剂1,4,6-雄甾三烯-3,17-二酮（ATD）的影响。

Horm Behav. 1988 Jun;22(2):252-65. doi: 10.1016/0018-506x(88)90070-0.

引用本文的文献

Sex and the developing brain: suppression of neuronal estrogen sensitivity by developmental androgen exposure.性别与发育中的大脑：发育过程中雄激素暴露对神经元雌激素敏感性的抑制作用。

Neurochem Res. 1997 Nov;22(11):1395-414. doi: 10.1023/a:1022027408234.

Multiple actions of steroids and their antagonists.

Arch Sex Behav. 1984 Oct;13(5):497-502. doi: 10.1007/BF01541432.

Exp Brain Res. 1986;64(3):407-10. doi: 10.1007/BF00340477.

Antibodies to 4-hydroxyandrostenedione--a new anti-breast cancer agent suitable for use in a radioimmunoassay.

Cancer Chemother Pharmacol. 1987;19(2):175-6. doi: 10.1007/BF00254575.

Anti-estrogen inhibition of testosterone-stimulated aggression in mice.抗雌激素对小鼠睾酮刺激的攻击行为的抑制作用。

Experientia. 1979 Feb 15;35(2):273-4. doi: 10.1007/BF01920660.

Recent advances in studies on estrogen biosynthesis.雌激素生物合成的研究新进展

J Endocrinol Invest. 1979 Oct-Dec;2(4):445-60. doi: 10.1007/BF03349349.

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