Satrija F, Nansen P, Murtini S, He S
Department of Veterinary Microbiology, Royal Veterinary and Agricultural University, Frederiksberg C, Denmark.
J Ethnopharmacol. 1995 Nov 3;48(3):161-4. doi: 10.1016/0378-8741(95)01298-r.
The purpose of this experiment was to study the possible anthelmintic activity of papaya latex (Carica papaya) against Heligmosomoides polygyrus in experimentally infected mice. Five groups of BALB/C mice were infected with 100 Heligmosomoides polygyrus infective larvae/mouse. After patency (day 22) four groups of mice (groups B, C, D and E) were given papaya latex suspended in water at dose levels of 2, 4, 6 and 8 g of papaya latex/kg body weight, respectively. One group of mice (group A) served as non-treated controls. All animals were necropsied on day 25, i.e. 3 days after treatment, for post-mortem worm counts. The papaya latex showed an antiparasitic efficacy of 55.5, 60.3, 67.9 and 84.5% in groups B, C, D and E, respectively. The results may suggest a potential role of papaya latex as an anthelmintic against patent intestinal nematodes of mammalian hosts.
本实验的目的是研究番木瓜乳胶（番木瓜）对实验感染小鼠体内多枝单睾线虫可能的驱虫活性。将五组BALB/C小鼠每组感染100条多枝单睾线虫感染性幼虫。在虫体成熟（第22天）后，四组小鼠（B、C、D和E组）分别给予以水悬浮的番木瓜乳胶，剂量水平分别为每千克体重2、4、6和8克番木瓜乳胶。一组小鼠（A组）作为未处理的对照。所有动物在第25天即治疗后3天进行剖检，以进行死后蠕虫计数。番木瓜乳胶在B、C、D和E组中的驱虫效果分别为55.5%、60.3%、67.9%和84.5%。结果可能表明番木瓜乳胶作为一种驱虫剂对哺乳动物宿主肠道内成熟线虫具有潜在作用。
