World Health Organ Tech Rep Ser. 1995;859:1-54.
This report presents the conclusions of a Joint FAO/WHO Expert Committee convened to evaluate the safety of various food additives and contaminants, with a view to recommending acceptable daily intakes for humans, and to prepare specifications for the identity and purity of food additives. The first part of the report contains a general discussion of principles governing the toxicological evaluation of food additives and contaminants, including flavouring agents, and the establishment and revision of specifications, with comments concerning limits for arsenic, lead and heavy metals. A summary follows of the Committee's evaluations of toxicological data on various specific food additives (including tert-butylhydroquinone, mineral oils, waxes and alitame) and on beta-cyclodextrin, nitrate, nitrite, potassium bromate and the contaminants ochratoxin A and patulin. Annexed to the report are a table summarizing the committee's recommendations for acceptable daily intakes of these substances and changes in the status of specifications, and a list of further toxicological studies required or desired.
本报告介绍了粮农组织/世卫组织联合专家委员会的结论。该委员会召开会议旨在评估各种食品添加剂和污染物的安全性，以便推荐人类每日可接受摄入量，并制定食品添加剂的身份和纯度规范。报告的第一部分对食品添加剂和污染物（包括调味剂）毒理学评估的相关原则以及规范的制定和修订进行了一般性讨论，并对砷、铅和重金属的限量发表了意见。接下来是委员会对各种特定食品添加剂（包括叔丁基对苯二酚、矿物油、蜡和阿力甜）以及β-环糊精、硝酸盐、亚硝酸盐、溴酸钾和污染物赭曲霉毒素A及展青霉素的毒理学数据评估总结。报告附件包括一个汇总委员会对这些物质每日可接受摄入量建议及规范状态变化的表格，以及一份所需或期望的进一步毒理学研究清单。
