Sawamoto N, Kaji R, Katayama M, Kubori T, Kimura J
Department of Neurology, Kyoto University School of Medicine, Japan.
Rinsho Shinkeigaku. 1995 Nov;35(11):1210-3.
A 29-year-old man suffered from dystonic writer's cramp for over three years. When he wrote, typed and did other tasks using right hand, dystonic involuntary movement triggered medial rotation of the arm, wrist extension and shoulder elevation. Medication, biofeedback, and botulinum injection were performed without much success. We tried to block the sensory input from muscles by using lidocaine and ethanol. We made injections of 0.5% lidocaine 50ml and 99% ethanol 5ml into muscles with abnormal activity at the frequency of twice a week for about six months. After the treatment, dystonic movement was remarkably improved and he was then able to write, type and perform other tasks with the right hand. Side effects included pain of the injection site, nausea and dizziness, which lasted for a few hours. This "muscle afferent block" did not cause muscle weakness. We speculate that muscle afferent plays a pivotal role in dystonia so that its blocking may be of clinical use.
一名29岁男性患张力障碍性书写痉挛已三年多。当他用右手书写、打字及进行其他任务时,张力障碍性不自主运动引发手臂内旋、手腕伸展和肩部抬高。药物治疗、生物反馈治疗及肉毒杆菌注射均效果不佳。我们尝试通过使用利多卡因和乙醇来阻断肌肉的感觉输入。我们以每周两次的频率,向活动异常的肌肉注射0.5%利多卡因50毫升和99%乙醇5毫升,持续约六个月。治疗后,张力障碍性运动明显改善,他随后能够用右手书写、打字及进行其他任务。副作用包括注射部位疼痛、恶心和头晕,持续数小时。这种“肌肉传入阻滞”未导致肌肉无力。我们推测肌肉传入在肌张力障碍中起关键作用,因此阻断它可能具有临床应用价值。