Combined NeuroScience IRB, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Department of Rehabilitation Medicine, National Institutes of Health, Bethesda, MD 20892, USA.
Toxins (Basel). 2017 Dec 29;10(1):20. doi: 10.3390/toxins10010020.
Selection of muscles for botulinum toxin injection for limb dystonia is particularly challenging. Limb dystonias vary more widely in the pattern of dystonic movement and involved muscles than cervical dystonia or blepharospasm. The large variation in how healthy individuals perform skilled hand movements, the large number of muscles in the hand and forearm, and the presence of compensatory actions in patients with dystonia add to the complexity of choosing muscles for injection. In this article, we discuss approaches to selecting upper and lower extremity muscles for chemodenervation treatment of limb dystonia.
选择用于治疗肢体肌张力障碍的肉毒毒素注射肌肉极具挑战性。与颈肌张力障碍或眼睑痉挛相比，肢体肌张力障碍的痉挛运动模式和受累肌肉差异更大。健康个体完成熟练手部运动的方式存在较大差异，手部和前臂的肌肉数量众多，且痉挛患者存在代偿动作，这些都增加了选择注射肌肉的复杂性。本文讨论了用于治疗肢体肌张力障碍的化学去神经治疗的上肢和下肢肌肉选择方法。
