[肉毒杆菌注射治疗书写痉挛]
[Writer's cramp treated with botulinum injections].
作者信息
Koelman J H, Struys M A, Ongerboer de Visser B W, Speelman J D
机构信息
Academisch Medisch Centrum, Amsterdam.
出版信息
Ned Tijdschr Geneeskd. 1998 Aug 1;142(31):1768-71.
OBJECTIVE
To evaluate the first clinical experience with local botulinum toxin A (BTA) injections in patients with writer's cramp.
DESIGN
Descriptive.
SETTING
Academic Medical Centre, Amsterdam, the Netherlands.
METHOD
In May 1993-January 1996 ten patients with writer's cramp were treated with BTA (Dysport). Age of the patients varied from 28 to 68 years, the duration of complaints from 1 to 29 years. Muscles for injections were selected by observation, sometimes combined with electromyography. BTA was administered under electromyographic guidance.
RESULTS
The amount of BTA administered per treatment session ranged from 15 to 400 IU. In three patients the BTA-induced weakness necessary to reach a beneficial effect on writing was unacceptable. In seven patients the response was satisfactory or good and lasted 2 to 15 months (mean: 3.5 months).
CONCLUSION
The results confirm the efficacy of BTA in writer's cramp.
目的
评估局部注射A型肉毒杆菌毒素（BTA）治疗书写痉挛患者的首次临床经验。
设计
描述性研究。
地点
荷兰阿姆斯特丹学术医疗中心。
方法
1993年5月至1996年1月，对10例书写痉挛患者采用BTA（Dysport）进行治疗。患者年龄在28至68岁之间，主诉持续时间为1至29年。通过观察选择注射肌肉，有时结合肌电图。在肌电图引导下注射BTA。
结果
每次治疗注射的BTA剂量为15至400国际单位。3例患者为达到对书写有益的效果而出现的BTA诱导的无力难以接受。7例患者的反应令人满意或良好，持续2至15个月（平均3.5个月）。
结论
结果证实了BTA治疗书写痉挛的有效性。
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