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（±）-8-羟基-2-（二正丙基氨基）四氢萘氢溴酸盐对麻醉的完整大鼠和脊髓横断大鼠脊髓运动系统的影响。

Effect of (+/-)-8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide on spinal motor systems in anesthetized intact and spinalized rats.

作者信息

Hasegawa Y, Ono H

机构信息

Department of Pharmacy, University of Tokyo, Japan.

出版信息

Eur J Pharmacol. 1996 Jan 11;295(2-3):211-4. doi: 10.1016/0014-2999(95)00759-8.

DOI:10.1016/0014-2999(95)00759-8
PMID:8720586
Abstract

In the present study, we examined the effect of the 5-HT1A receptor agonist (+/-)-8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide (8-OH-DPAT), on the mono- and polysynaptic reflexes in intact and spinalized rats. 8-OH-DPAT (10 micrograms/kg i.v.) significantly potentiated the amplitude of the monosynaptic reflex in intact rats. In contrast, 8-OH-DPAT (30 and 100 micrograms/kg i.v.) produced a significant dose-related inhibition of the amplitude of the monosynaptic reflex in spinalized rats. These results suggest that 8-OH-DPAT predominantly excites spinal motor systems at the supraspinal site, and inhibits such systems at a spinal cord site.

摘要

在本研究中，我们检测了5-羟色胺1A受体激动剂（±）-8-羟基-2-（二正丙基氨基）四氢萘氢溴酸盐（8-OH-DPAT）对完整大鼠和脊髓横断大鼠单突触和多突触反射的影响。8-OH-DPAT（静脉注射10微克/千克）显著增强了完整大鼠单突触反射的幅度。相反，8-OH-DPAT（静脉注射30和100微克/千克）对脊髓横断大鼠的单突触反射幅度产生了显著的剂量依赖性抑制。这些结果表明，8-OH-DPAT主要在脊髓以上部位兴奋脊髓运动系统，而在脊髓部位抑制该系统。

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Spinal 5-HT-receptors and tonic modulation of transmission through a withdrawal reflex pathway in the decerebrated rabbit.
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