Doi Y, Yoshizumi H, Yoshinari M, Iino K, Yamamoto M, Ichikawa K, Iwase M, Fujishima M
Second Department of Internal Medicine, Kyushu University, Fukuoka, Japan.
Diabetologia. 1996 Jan;39(1):97-102. doi: 10.1007/BF00400419.
The relationship between diabetic nephropathy and an insertion (I)/deletion (D) polymorphism in intron 16 of the angiotensin-converting enzyme (ACE) gene is still under debate. The association of ACE gene polymorphism with nephropathy and retinopathy was therefore examined in 362 Japanese patients with non-insulin-dependent diabetes mellitus (NIDDM) and 105 healthy control subjects. Distribution of the ACE genotype did not differ between healthy control subjects and diabetic patients without complications. However, the frequency of the D allele was significantly higher in the diabetic subjects with nephropathy than in those without (0.32 in normoalbuminuric patients vs 0.44 in albuminuria patients with albuminuria) (chi 2 = 7.7; p = 0.006). There was no significant association between ACE genotype and retinopathy. These observations thus demonstrate a significant association of the ACE gene polymorphism with nephropathy, but not with retinopathy, in Japanese patients with NIDDM.
血管紧张素转换酶（ACE）基因第16内含子插入（I）/缺失（D）多态性与糖尿病肾病之间的关系仍存在争议。因此，我们在362例日本非胰岛素依赖型糖尿病（NIDDM）患者和105例健康对照者中研究了ACE基因多态性与肾病和视网膜病变的相关性。健康对照者与无并发症的糖尿病患者之间ACE基因型分布无差异。然而，有肾病的糖尿病患者中D等位基因频率显著高于无肾病者（正常白蛋白尿患者为0.32，白蛋白尿患者为0.44）（χ2 = 7.7；p = 0.006）。ACE基因型与视网膜病变之间无显著相关性。这些观察结果表明，在日本NIDDM患者中，ACE基因多态性与肾病显著相关，但与视网膜病变无关。
