Brownell J E, Allis C D
Department of Biology, University of Rochester, New York 14627-0211, USA.
Curr Opin Genet Dev. 1996 Apr;6(2):176-84. doi: 10.1016/s0959-437x(96)80048-7.
Post-translational acetylation of the core histone amino-terminal tails has long been associated with both chromatin assembly and the regulation of gene expression. The recent identification and cloning of histone acetyltransferase genes represents a significant breakthrough in our understanding of how specific acetylation states are established. Ongoing characterization of these enzymes and their molecular cohorts supports a direct role for acetylation in a signaling pathway that modulates chromatin structure to create new patterns of transcription.
核心组蛋白氨基末端尾巴的翻译后乙酰化长期以来一直与染色质组装和基因表达调控相关。最近组蛋白乙酰转移酶基因的鉴定和克隆代表了我们在理解特定乙酰化状态如何建立方面的重大突破。对这些酶及其分子伙伴的持续表征支持了乙酰化在调节染色质结构以创造新转录模式的信号通路中的直接作用。
