McColl K E, el-Omar E
University Dept. of Medicine & Therapeutics, Western Infirmary, Glasgow, UK.
Scand J Gastroenterol Suppl. 1996;215:32-7. doi: 10.3109/00365529609094531.
Helicobacter pylori is now recognized as the major acquired factor in the pathogenesis of duodenal ulcer disease (DU). There is also an association between H. pylori infection and the subsequent development of gastric cancer. The mechanisms by which such infection predisposes the host to these diseases are incompletely understood, but disorders induced by the bacterium in gastric function play a pivotal role. In most patients, H. pylori infection stimulates acid secretion, leading to a predisposition to DU development. However, in some patients, the infection is associated with a significant decrease in acid secretion, a predisposition to gastric cancer. These divergent effects of H. pylori on gastric acid secretion explain the early conflicting reports on changes in acid secretion associated with the infection. The reason why H. pylori infection produces divergent effects on gastric acid secretion is unclear, but may be related to differences in bacterial strains or genetic, dietary or other environmental factors.
幽门螺杆菌现已被公认为是十二指肠溃疡病（DU）发病机制中的主要后天因素。幽门螺杆菌感染与随后胃癌的发生之间也存在关联。这种感染使宿主易患这些疾病的机制尚未完全明了，但该细菌引起的胃功能紊乱起着关键作用。在大多数患者中，幽门螺杆菌感染会刺激胃酸分泌，从而导致易患十二指肠溃疡。然而，在一些患者中，感染与胃酸分泌显著减少有关，这是易患胃癌的因素。幽门螺杆菌对胃酸分泌的这些不同影响解释了早期关于与该感染相关的胃酸分泌变化的相互矛盾的报道。幽门螺杆菌感染对胃酸分泌产生不同影响的原因尚不清楚，但可能与菌株差异或遗传、饮食或其他环境因素有关。
