McColl K E, el-Omar E, Gillen D
Department of Medicine & Therapeutics, Gardiner Institute, Western Infirmary, Glasgow, UK.
Br Med Bull. 1998;54(1):121-38. doi: 10.1093/oxfordjournals.bmb.a011663.
There is evidence of a two-way interaction between gastric acid secretion and H. pylori-associated gastritis. Gastric acid secretion influences the density of H. pylori colonisation, its distribution within the stomach and the severity of the mucosal inflammatory response to the infection. In addition, H. pylori gastritis alters gastric acid secretion. In subjects with a predominant antral gastritis, it increases acid secretion predisposing to duodenal ulcer, whereas in others with predominant body gastritis, acid secretion is impaired and the subjects have an increased risk of gastric cancer. The two-way interaction between acid secretion and H. pylori gastritis is observed when H. pylori-positive subjects are treated with proton pump inhibitor agents. The inhibition of acid secretion induces a body gastritis and this inflammation of the body mucosa inhibits acid secretion thus augmenting the anti-secretory effect of the drug. In this article, we discuss the interaction between gastric acid secretion and H. pylori gastritis and its importance in determining disease outcome.
有证据表明胃酸分泌与幽门螺杆菌相关性胃炎之间存在双向相互作用。胃酸分泌会影响幽门螺杆菌的定植密度、其在胃内的分布以及对感染的黏膜炎症反应的严重程度。此外，幽门螺杆菌胃炎会改变胃酸分泌。在以胃窦为主的胃炎患者中，它会增加胃酸分泌，易引发十二指肠溃疡，而在以胃体为主的胃炎患者中，胃酸分泌受损，这些患者患胃癌的风险增加。当幽门螺杆菌阳性患者接受质子泵抑制剂治疗时，可观察到胃酸分泌与幽门螺杆菌胃炎之间的双向相互作用。胃酸分泌的抑制会引发胃体胃炎，而这种胃体黏膜炎症会抑制胃酸分泌，从而增强药物的抗分泌作用。在本文中，我们讨论了胃酸分泌与幽门螺杆菌胃炎之间的相互作用及其在决定疾病转归中的重要性。
