van Hoogdalem E J, Terpstra I J, Baven A L
Yamanouchi Europe B.V., Research Labs., Leiderdorp, Netherlands.
Skin Pharmacol. 1996;9(2):104-10. doi: 10.1159/000211405.
Erythromycin with or without additional zinc acetate is used topically in the treatment of acne vulgaris. A potential effect of zinc on the stratum corneum penetration of erythromycin was investigated in human volunteers. Skin surface washings and tape strippings from the skin of the back were collected after drug applications in 12 subjects for quantification of erythromycin levels. Zinc acetate increased the amount remaining on the back skin at 6 h after application from 40 +/- 19 to 56 +/- 15% of the dose and, vice versa, reduced the amount in stratum corneum strips from 22 +/- 7 to 18 +/- 7%, both with statistical significance. The effect varied with body region. Zinc acetate thus provided to prolong the residence time of erythromycin on the skin.
单独使用或与额外的醋酸锌联合使用的红霉素被局部用于治疗寻常痤疮。在人类志愿者中研究了锌对红霉素经角质层渗透的潜在影响。在12名受试者用药后，收集背部皮肤的表面冲洗液和胶带剥离物，以定量红霉素水平。醋酸锌使用药后6小时背部皮肤残留量从剂量的40±19%增加到56±15%，反之，角质层条带中的量从22±7%减少到18±7%，两者均具有统计学意义。该效应因身体部位而异。因此，醋酸锌可延长红霉素在皮肤上的停留时间。
