秀丽隐杆线虫的sel-1基因是lin-12和glp-1的负调控因子，编码一种预测的细胞外蛋白。
The Caenorhabditis elegans sel-1 gene, a negative regulator of lin-12 and glp-1, encodes a predicted extracellular protein.
作者信息
Grant B, Greenwald I
机构信息
Department of Molecular Biology, Princeton University, New Jersey 08544, USA.
出版信息
Genetics. 1996 May;143(1):237-47. doi: 10.1093/genetics/143.1.237.
Abstract
The Caenorhabditis elegans lin-12 and glp-1 genes encode members of the LIN-12/NOTCH family of receptors. The sel-1 gene was identified as an extragenic suppressor of a lin-12 hypomorphic mutant. We show in this report that the sel-1 null phenotype is wild type, except for an apparent elevation in lin-12 and glp-1 activity in sensitized genetic backgrounds, and that this genetic interaction seems to be lin-12 and glp-1 specific. We also find that sel-1 encodes a predicted extracellular protein, with a domain sharing sequence similarity to predicted proteins from humans and yeast. SEL-1 may interact with the LIN-12 and GLP-1 receptors and/or their respective ligands to down-regulate signaling.
摘要
秀丽隐杆线虫的lin-12和glp-1基因编码LIN-12/NOTCH受体家族的成员。sel-1基因被鉴定为lin-12亚等位基因突变体的基因外抑制因子。我们在本报告中表明，sel-1基因敲除的表型是野生型，除了在敏感的遗传背景下lin-12和glp-1活性明显升高外，并且这种遗传相互作用似乎是lin-12和glp-1特有的。我们还发现sel-1编码一种预测的细胞外蛋白，其一个结构域与来自人类和酵母的预测蛋白具有序列相似性。SEL-1可能与LIN-12和GLP-1受体和/或它们各自的配体相互作用以下调信号传导。
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Genetic and Phenotypic Characterization of Roller Mutants of CAENORHABDITIS ELEGANS.秀丽隐杆线虫 Roller 突变体的遗传和表型特征。
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The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development.daf-4基因编码一种控制秀丽隐杆线虫 dauer 幼虫发育的骨形态发生蛋白受体。
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