Levitan D, Greenwald I
Department of Molecular Biology, Princeton University, New Jersey 08544, USA.
Nature. 1995 Sep 28;377(6547):351-4. doi: 10.1038/377351a0.
The lin-12 and glp-1 genes of Caenorhabditis elegans are members of the lin-12/Notch family of receptors for intercellular signals that specify cell fate. By screening for suppressors of a lin-12 gain-of-function mutation, we identified a new gene, sel-12, which appears to function in receiving cells to facilitate signalling mediated by lin-12 and glp-1. The sel-12 gene encodes a protein with multiple transmembrane domains, and is similar to S182, which has been implicated in early-onset familial Alzheimer's disease. The high degree of sequence conservation suggests that the function of the SEL-12 and S182 proteins may also be conserved.
秀丽隐杆线虫的lin-12和glp-1基因是lin-12/Notch家族的成员，该家族是用于指定细胞命运的细胞间信号受体。通过筛选lin-12功能获得性突变的抑制因子，我们鉴定出一个新基因sel-12，它似乎在接收细胞中发挥作用，以促进由lin-12和glp-1介导的信号传导。sel-12基因编码一种具有多个跨膜结构域的蛋白质，与S182相似，后者与早发性家族性阿尔茨海默病有关。高度的序列保守性表明SEL-12和S182蛋白的功能可能也具有保守性。
