Cole G T, Halawa A A, Anaissie E J
Department of Microbiology, Medical College of Ohio, Toledo 43699, USA.
Clin Infect Dis. 1996 May;22 Suppl 2:S73-88. doi: 10.1093/clinids/22.supplement_2.s73.
The gastrointestinal (GI) tract is a frequent source of hematogenous candidiasis in humans. Animal models of GI and hematogenous candidiasis have provided insights into the nature of candidal infection of host mucosal tissue, mechanisms of fungal dissemination to body organs, and features of host response to candidal infections. Biological systems such as these that simulate human candidiasis can be used for testing novel antifungal drugs. We have focused on two murine models of candidiasis with similarities to this fungal disease in humans. The first model simulates a commensal association of Candida albicans with the GI tract of immunocompetent hosts; it has permitted studies of innate and immune cell response to long-term ( > 60 days) infection of the esophageal, gastric, and intestinal mucosa. The second model simulates candidal infection in granulocytopenic patients with invasive candidiasis that originated from sites of colonization in the gut. Both models are well suited for investigating new approaches to prevention and treatment of hematogenous candidiasis. A review of the data on the role of GI candidiasis in hematogenous candidal infections is presented.
胃肠道是人类血源性念珠菌病的常见来源。胃肠道和血源性念珠菌病的动物模型为深入了解宿主黏膜组织念珠菌感染的本质、真菌播散至身体器官的机制以及宿主对念珠菌感染的反应特征提供了线索。这类模拟人类念珠菌病的生物系统可用于测试新型抗真菌药物。我们重点研究了两种与人类这种真菌疾病相似的念珠菌病小鼠模型。第一种模型模拟白色念珠菌与免疫功能正常宿主胃肠道的共生关系；它使得对食管、胃和肠道黏膜长期（>60天）感染的固有免疫和免疫细胞反应的研究成为可能。第二种模型模拟粒细胞减少患者的侵袭性念珠菌病，该病起源于肠道定植部位。这两种模型都非常适合研究预防和治疗血源性念珠菌病的新方法。本文对胃肠道念珠菌病在血源性念珠菌感染中的作用的数据进行了综述。
