Salimi A, Oliver G C, Lee J, Sherman L A
Circulation. 1977 Aug;56(2):213-7. doi: 10.1161/01.cir.56.2.213.
This study measured the growth over time of experimental coronary artery (CA) thrombi by radiolabeled fibrinogen uptake. 125I-fibrinogen was injected into dogs and 24 hours later CA thrombi were induced by electrical current. Twenty-four hours after CA thrombus induction, 131I-albumin (group A) or 131I-fibrinogen (group B) was injected. At 48 hours after thrombi induction, the thrombi were removed, divided into segments, and their radioactivity measured. The 131I-fibrinogen in the group B thrombi was significantly greater than the 131I-albumin in group A thrombi (P less than 0.001). In further studies, the 131I-fibrinogen was given 48 and 72 hours post CA thrombus formation. Significant 131I was also found in these CA thrombi. 125I-fibrinogen and 131I-fibrinogen incorporation occurred in virtually all segments of the thrombi. The results suggest 1) CA thrombi growth continues for at least 72 hours after initial formation; 2) the presence of 131I in the thrombi was due to gradual fibrin deposition throughout the thrombus.
本研究通过放射性标记纤维蛋白原摄取来测量实验性冠状动脉（CA）血栓随时间的生长情况。将125I-纤维蛋白原注入犬体内，24小时后通过电流诱导CA血栓形成。在CA血栓形成后24小时，注入131I-白蛋白（A组）或131I-纤维蛋白原（B组）。在血栓形成后48小时，取出血栓，分成片段，并测量其放射性。B组血栓中的131I-纤维蛋白原显著高于A组血栓中的131I-白蛋白（P小于0.001）。在进一步的研究中，在CA血栓形成后48小时和72小时给予131I-纤维蛋白原。在这些CA血栓中也发现了显著的131I。125I-纤维蛋白原和131I-纤维蛋白原几乎在血栓的所有片段中都有掺入。结果表明：1）CA血栓在初始形成后至少持续生长72小时；2）血栓中131I的存在是由于整个血栓中纤维蛋白的逐渐沉积。
