Moschos C B, Oldewurtel H A, Haider B, Regan T J
Circulation. 1976 Oct;54(4):653-6. doi: 10.1161/01.cir.54.4.653.
A study was carried out to define the time limits during which an experimental coronary thrombus remains capable of incorporating fibrinogen. 131I-fibrinogen was given to intact anesthetized dogs at different time intervals, up to 67 hours, following the formation of a coronary thrombus by catheter-electrode. Radioactivity of the recovered thrombi as a whole and segmentally divided, was determined following variable time intervals of exposure to circulating fibrinogen and was expressed as thrombus/blood ratio. The results indicate that coronary thrombi formed in a normal coronary vessel remain capable of incorporating fibrinogen for at least eighteen hours, with no significant differences in the segmental distribution of radioactivity. These findings do not support the view that the recovery of isotopic fibrinogen, which was given after the onset of coronary symptoms, in thrombi from patients with myocardial infarction establishes that the thrombus was initiated after the ischemic process.
进行了一项研究以确定实验性冠状动脉血栓在多长时间内仍能够结合纤维蛋白原。在通过导管电极形成冠状动脉血栓后的不同时间间隔（最长67小时），给完整的麻醉犬注射131I - 纤维蛋白原。在暴露于循环纤维蛋白原的不同时间间隔后，测定回收血栓整体及分段后的放射性，并以血栓/血液比值表示。结果表明，在正常冠状动脉血管中形成的冠状动脉血栓至少18小时内仍能够结合纤维蛋白原，放射性的分段分布无显著差异。这些发现不支持以下观点，即心肌梗死患者血栓中在冠状动脉症状出现后给予的同位素纤维蛋白原的回收表明血栓是在缺血过程之后形成的。
