更昔洛韦-萘啶酸抗病毒化疗对鸭乙型肝炎病毒DNA复制的抑制作用
Inhibition of duck hepatitis B virus DNA replication by antiviral chemotherapy with ganciclovir-nalidixic acid.
作者信息
Wang Y, Luscombe C, Bowden S, Shaw T, Locarnini S
机构信息
Macfarlane Burnet Centre for Medical Research, Fairfield Hospital, Victoria, Australia.
出版信息
Antimicrob Agents Chemother. 1995 Feb;39(2):556-8. doi: 10.1128/AAC.39.2.556.
Abstract
The aim of this study was to examine the effects of ganciclovir and nalidixic acid either alone or in combination on duck hepatitis B virus DNA replication in vivo with particular reference to production of viral supercoiled DNA and RNA. The most effective antiviral response was observed in the livers of ducks treated by the combination therapy for 28 days, which resulted in a substantial decrease in the amounts of viral supercoiled DNA, relaxed circular and single-stranded DNA, and also viral RNA. This combination treatment was not hepatotoxic over the study period.
摘要
本研究的目的是考察更昔洛韦和萘啶酸单独或联合使用对鸭乙型肝炎病毒DNA在体内复制的影响，特别是对病毒超螺旋DNA和RNA产生的影响。在接受联合治疗28天的鸭肝脏中观察到最有效的抗病毒反应，这导致病毒超螺旋DNA、松弛环状和单链DNA以及病毒RNA的量大幅减少。在研究期间，这种联合治疗没有肝毒性。
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