Basilisco G, Carola F, Vanoli M, Bianchi P, Barbera R
Department of Gastroenterology, IRCCS Ospedale Maggiore, Università degli Studi di Milano, Italy.
Eur J Gastroenterol Hepatol. 1996 Mar;8(3):205-9. doi: 10.1097/00042737-199603000-00004.
To test the effect of body position on oesophageal acid clearance time in patients with systemic sclerosis.
Fifteen consecutive patients with systemic sclerosis and six healthy subjects underwent oesophageal manometry and an acid clearance test in three body positions (supine, recumbent at 30 degrees and seated at 90 degrees) in randomized order.
In healthy subjects the body position did not affect acid clearance time, whereas in patients the oesophagus cleared mainly by gravity. In patients the acid clearance time was significantly longer in the supine than in the seated position (P < 0.05). Nine patients did not have a detectable peristaltic wave in the distal oesophagus. In the other six oesophageal peristalsis was still detectable but contractions had reduced amplitude and often had double and triple peaks; also in this subgroup the acid clearance time recorded in the supine position was prolonged.
In systemic sclerosis gravity plays a major role in oesophageal acid clearance time. The finding of delayed acid clearance in a supine patient may suggest initial oesophageal involvement in the disease.
检测体位对系统性硬化症患者食管酸清除时间的影响。
15例连续的系统性硬化症患者和6名健康受试者按随机顺序在三种体位（仰卧位、30度斜卧位和90度坐位）下接受食管测压和酸清除试验。
在健康受试者中，体位不影响酸清除时间，而在患者中食管主要靠重力清除。患者仰卧位时的酸清除时间显著长于坐位（P<0.05）。9例患者在食管远端未检测到蠕动波。在另外6例中，仍可检测到食管蠕动，但收缩幅度减小，且常出现双峰和三峰；在该亚组中，仰卧位记录的酸清除时间也延长。
在系统性硬化症中，重力在食管酸清除时间中起主要作用。仰卧位患者酸清除延迟的发现可能提示疾病早期食管受累。
