Gil A I, Lanata C F, Butron B, Gabilondo A, Molina M, Bravo N
Instituto de Investigación Nutricional, Lima, Peru.
Pediatr Infect Dis J. 1996 May;15(5):415-8. doi: 10.1097/00006454-199605000-00007.
To determine the incidence of Vibrio cholerae O1-associated diarrhea in children during the onset of the 1991 cholera epidemic in Peru.
Stool cultures were obtained from children (mean age, 26 months) participating in a prospective community-based study of diarrhea in a periurban community in Lima between February and May, 1991.
Of the 409 diarrheal episodes cultured V. cholerae O1 was isolated in 14 (3.4%) episodes. This represented an incidence of 0.11 episode per child year, higher than previously reported rates in children from endemic cholera areas. Most cases were mild; only 1 case required hospitalization.
Our study indicates that from the beginning of this epidemic, V. cholerae O1 caused diarrhea in children as well as adults and should therefore be considered as one of the possible pathogens when children from a cholera-affected area develop diarrhea.
确定1991年秘鲁霍乱流行初期儿童中与霍乱弧菌O1相关腹泻的发病率。
从1991年2月至5月参与利马城郊社区一项基于社区的腹泻前瞻性研究的儿童（平均年龄26个月）中获取粪便培养物。
在409次腹泻发作的培养物中，14次（3.4%）分离出霍乱弧菌O1。这相当于每名儿童每年0.11次发作的发病率，高于此前报道的霍乱流行地区儿童的发病率。大多数病例为轻症；仅1例需要住院治疗。
我们的研究表明，自此次疫情开始，霍乱弧菌O1在儿童和成人中均引起腹泻，因此当霍乱疫区的儿童出现腹泻时，应将其视为可能的病原体之一。
