Hiraga T, Shimada M, Okubo M, Nakanishi K, Kobayashi T, Murase T
Department of Endocrinology and Metabolism, Toranomon Hospital, Tokyo, Japan.
Atherosclerosis. 1996 Apr 26;122(1):29-32. doi: 10.1016/0021-9150(95)05743-9.
In an attempt to ascertain whether Lp(a) is a risk factor for multiple cerebral infarctions (MCI), we have studied 83 patients with proven MCI and 39 subjects without MCI by computed tomography (CT). Seventy-one patients with non-insulin-dependent diabetes mellitus (NIDDM) were included: 52 with and 19 without MCI. Serum Lp(a) levels were significantly higher in patients with MCI than in subjects without MCI. There were no differences in serum Lp(a) levels between NIDDM and non-diabetic patients with MCI. The logistic regression analysis revealed that Lp(a) and hypertension were independent risk factors for the cerebral event. The current study demonstrated that Lp(a) and hypertension are significant risk factors for multiple cerebral infarctions.
为了确定脂蛋白(a)[Lp(a)]是否为多发性脑梗死（MCI）的危险因素，我们通过计算机断层扫描（CT）研究了83例经证实患有MCI的患者和39例无MCI的受试者。纳入了71例非胰岛素依赖型糖尿病（NIDDM）患者：52例患有MCI，19例未患MCI。MCI患者的血清Lp(a)水平显著高于无MCI的受试者。NIDDM患者与非糖尿病MCI患者的血清Lp(a)水平无差异。逻辑回归分析显示，Lp(a)和高血压是脑部事件的独立危险因素。当前研究表明，Lp(a)和高血压是多发性脑梗死的重要危险因素。
