异丙肾上腺素对人体血浆肾素活性的影响：剂量-反应曲线

The effect of isoprenaline on plasma renin activity in man: a dose-response curve.

作者信息

Davies R, Slater J D, Rudolf M, Geddes D M

出版信息

Clin Endocrinol (Oxf). 1977 May;6(5):395-9. doi: 10.1111/j.1365-2265.1977.tb02026.x.

DOI:10.1111/j.1365-2265.1977.tb02026.x

Abstract

Four normal subjects on a free sodium intake received intravenous isoprenaline in doses of 2, 4, 8 and 16 microgram over 2 min. Three of the subjects received a second infusion of 8 microgram. The rate of renin release indexed by changes in plasma renin activity increased in all subjects at each dose level. The mean peak levels of plasma renin were 9%, 29% and 77% above the mean control levels at doses of 2, 4 and 8 microgram respectively. The response of 16 microgram was no different from that seen with 8 microgram. The renin response obtained at 8 microgram was highly reproducible such that the coefficient of variation for duplicate estimations of plasma renin (twelve duplicates) ranged from 1.7 to 4%.

摘要

四名正常受试者在自由摄入钠的情况下，在2分钟内静脉注射剂量分别为2、4、8和16微克的异丙肾上腺素。其中三名受试者接受了第二次8微克的输注。以血浆肾素活性变化为指标的肾素释放率在每个剂量水平的所有受试者中均升高。血浆肾素的平均峰值水平在剂量为2、4和8微克时分别比平均对照水平高9%、29%和77%。16微克剂量的反应与8微克时无差异。8微克时获得的肾素反应具有高度可重复性，血浆肾素重复测定（十二次重复）的变异系数范围为1.7%至4%。